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K. K. Rajasekhar ¹, V. Shankarananth ¹, M. Rajagowtham ¹, B. Gowtham Kumar ¹, B. Thejnayan ¹, M. Pavankumar ¹

Affiliations
1 Dept of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P., IN

Abstract

This work evaluated the local anaesthetic activity of milky latex obtained from Calotropis gigantea using three different experimental models in frog and Guinea pig. The latex at dilution 1:10 showed the anaesthetic activity compared to the standard drug xylocaine (0.2%). The methods used are nerve block or lumbar plexus anaesthesia and muscle twitch in frog, infiltration anaesthesia in Guinea pig. It was concluded that latex of Calotropis gigantea (1:10 dilution ) exhibited significant local anaesthetic activity.

Keywords

Calotropis Gigantea, Milky Latex, Local Anaesthetic Activity, Nerve Block Method, Muscle Twitch Method and Infiltration Method.

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K. K. Rajasekhar ¹, V. Shankarananth ¹, C. Sreelakshmi ¹, A. Sushmitha ¹, S. Ch. Moulali ¹, V. Swetha Reddy ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., IN

Abstract

The present work describes the potentiation of local anesthetic activity exhibited by milky latex obtained from Calotropis gigantea, with epinephrine and pH. The milky latex at a dilution of 1:10, exhibited significant local anesthetic activity. Both epinephrine (5μg/ml) and pH of 7.2 prolonged the duration of local anesthetic activity. The method used is infiltration anesthesia in Guinea pig. In conclusion, the duration of the effect produced by combination of Calotropis gigantea latex and epinephrine was longer than the combination of latex and pH as well as latex alone.

Keywords

Calotropis Gigantea, Milky Latex, Epinephrine, pH and Infiltration Anesthesia.

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C. Girish ¹, S. Vineela ², Y. Narasimha Reddy ³, O. V. S. Reddy ⁴, K. K. Rajasekhar ⁵, V. Shankarananth ⁵

Affiliations
1 Division of Pharmacy, Dept of Biochemistry, S.V. University, Tirupati.–517-501, IN
2 MAM College of Pharmacy, Narsaraopet, Guntur, IN
3 University College of Pharmaceutical Sciences, Kakatiya University, Warangal, IN
4 Dept of Biochemistry S.V. University, Tirupati.517-501, IN
5 Sri Padmavathi School of Pharmacy, Tirupati, IN

Abstract

The anti-ulcer activity aqueous extract of leaves of Coccinia grandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Coccinia grandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (250 mg/kg&500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Coccinia grandis have potential antiulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Keywords

Coccinia grandis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Omeprazole.

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V. Sreedhar ¹, L. K. Ravindra Nath ², N. Madana Gopal ³, K. Venu Gopal ⁴, D. Raju ³, K. K. Rajasekhar ⁵

Affiliations
1 Deparment of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, IN
2 Department of Chemistry, Srikrishna Devaraya University, Anantapur, A.P, IN
3 Department of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, IN
4 Dept of Pharmacy, Nirmala College of Pharmacy, Kadapa, A.P, IN
5 Departement of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi-517503, A.P, IN

Abstract

Methanolic extracts of Vitex quinata ischolar_mains at 200, 400 and 800 mg/kg and silymarin was prepared and tested for its hepatoprotective effect against paracetamol induced hepatitis in rats. Alteration in the level of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, TPL, CHL, TPTN and ALP were tested in both treated and untreated groups. The methanolic extracts of Vitex quinata ischolar_mains at 200,400 and 800 mg/kg and silymarin showed a significant (P<0.05) decrease in all the elevated SGOT, SGPT, ALKP, TBL, CHL and significant increase (P<0.05) in TPTN and ALB levels produced by the toxicant Paracetamol.

Keywords

Vitex quinata, Antioxidant Activity, Ascorbic Acid.

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Y. Rajendraprasad ¹, M. Bhagavan Raju ², K. K. Rajasekhar ³, S. Sowjanya ³

Affiliations
1 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, AP, IN
2 CMR College of Pharmacy, Hyderabad, AP, IN
3 Dept. of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, AP, IN

Abstract

The present work describes the insilico prodrug designing of Tanomastat, a matrix metalloproteinase inhibitor. Tanomastat was selected as a lead and a series of prodrug-like molecules derived from it were generated. The pharmacokinetic and toxicity profile of these prodrug-like molecules was obtained by using ADME and TOX boxes web version of pharma Algorithms and ACD labs Chem Sketch software version 12.0. All prodrug-like molecules were predicted to be lipophilic, less toxic with an enhanced protein binding and better therapeutic efficacy. In conclusion, ADME and Toxicity properties of these molecules suggest advantages over Tanomastat.

Keywords

Insilico Prodrug Designing, Tanomastat, Matrix Metallo Proteinase Inhibitor (MMPI), Pharmacokinetic and Toxicity Profile.

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Y. Rajendraprasad ¹, K. K. Rajasekhar ², V. Shankarananth ², S. Bharath Kumar ², G. Dileep Kumar ², T. Sreelekha ²

Affiliations
1 Department of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, A.P, IN
2 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, IN

Abstract

The Present work describes a simple reverse phase HPLC method for the estimation of Domperidone in bulk and pharmaceutical formulations. The estimation was carried out on Gemini, Phenomonex, C-18 (250×4.6 mm, 5 μ) column using a mobile phase consisting of potassium dihydrogen phosphate buffer-Acetonitrile-Methanol (40:30:30). The eluent was monitored at 288 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.

Keywords

HPLC Estimation, Validation, Domperidone and Pharmaceutical Formulation.

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